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Publications
 
Mitochondrial biogenesis in the parasitic protozoa
Trypanosoma brucei
 
Research group of André Schneider
 
Address of the Department
 

   
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ALL 2017 2012 2011

 

Peikert C. D., Mani J., Morgenstern M., Käser S., Knapp B., Wenger C., Harsman A., Oeljeklaus S., Schneider A., and Warscheid B. (2017) 
Charting organellar importomes by quantitative mass spectrometry
Nat. Commun. in press

Bruggisser J., Käser S., Mani J. and Schneider A. (2017)
Biogenesis of a mitochondrial outer membrane protein in Trypanosoma brucei: targeting signal and dependence on an unique biogenesis factor.
J. Biol. Chem. 292: 3400-3410

Harsman A. and Schneider A. (2017)
Mitochondrial protein import in trypanosomes - Expect the unexpected
Traffic 18:96-109 / Review

Mani J., Rout S., Desy S. and Schneider A. (2017)
Mitochondrial protein import - Functional analysis of the highly diverged Tom22 orthologue of Trypanosoma brucei
Sci. Rep. 7, 40738

Harsman A., Oeljeklaus S., Wenger C., Huot J. L., Warscheid B. and Schneider A. (2016)
The non-canonical mitochondrial inner membrane presequence translocase of trypanosomatids contains two essential rhomboid-like proteins
Nat. Commun. 7: 13707

Desy S., Mani J., Harsman A., Käser S. and Schneider A. (2016)
TbLOK1/ATOM19 is a novel subunit of the noncanonical mitochondrial outer membrane protein translocase of Trypanosoma brucei
Mol. Microbiol. 102:520-529

Käser S., Oeljeklaus S., Týč J., Vaughan S., Warscheid B. and Schneider A. (2016)
Outer membrane protein functions as integrator of protein import and DNA inheritance in mitochondria
Proc. Natl. Acad. Sci. USA 113: E4467-E4475

Mani J., Meisinger C. and Schneider A. (2016)
Peeping at TOMs - Diverse entry gates to mitochondria provide insights into the evolution of eukaryotes
Mol. Biol. Evol. 33:337-351 / Review

Farine L., Niemann M., Schneider A. and Bütikofer P. (2015)
Phosphatidylethanolamine and phosphatidylcholine biosynthesis by the Kennedy pathway occurs at different sites in Trypanosoma brucei
Sci. Rep. 5: 16787

Albisetti. A., Wiese S., Schneider A. and Niemann M. (2015)
A component of the mitochondrial outer membrane proteome of T. brucei probably contains covalent bound fatty acids.
Exp. Parasitol. 155:49-57

de Macêdo J. P., Schumann Burkard G., Niemann M., Barrett M. P., Vial H., Mäser P., Roditi I., Schneider A., Bütikofer P. (2015)
An Atypical Mitochondrial Carrier That Mediates Drug Action in Trypanosoma brucei.
PLoS Pathog. 6: e1004875

Mani J., Desy S., Niemann M., Chanfon A., Oeljeklaus S., Pusnik M., Schmidt O., Gerbeth C., Meisinger C., Warscheid B., Schneider A. (2015)
Mitochondrial protein import receptors in Kinetoplastids reveal convergent evolution over
large phylogenetic distances
.
Nat Commun. 6:6646

Schneider A. and Schnarwiler F. (2014)
Parasite reveals mitochondrial inheritance machinery
Chimia 68: 749 / Review

Schnarwiler F., Niemann M., Doiron N., Harsman A., Käser S., Mani J., Chanfon A., Dewar C. E., Oeljeklaus S., Jackson C. B., Pusnik M., Schmidt O., Meisinger C., Hiller S., Warscheid B., Schnaufer A. C., Ochsenreiter T. and Schneider A. (2014)
Trypanosomal TAC40 constitutes a novel subclass of mitochondrial β-barrel proteins specialized in mitochondrial genome inheritance.
Proc. Natl. Acad. Sci. USA, 111:7624-7629

Cristodero M., Mani J., Oeljeklaus S., Aeberhard L., Hashimi H., Ramrath D. J., Lukeš J., Warscheid B. and Schneider A. (2013)
Mitochondrial translation factors of Trypanosoma brucei: elongation factor-Tu has a unique subdomain that is essential for its function
Mol. Microbiol. 90:744-755

*Niemann M., *Wiese S., Mani J., Chanfon A., Jackson C. , Meisinger C., *Warscheid B. and *Schneider A. (2013) (joint first and joint corresponding authors)
Mitochondrial outer membrane proteome of Trypanosoma brucei reveals novel factors required to maintain mitochondrial morphology
Mol. Cell. Proteomics, 12:515-28

Harsman A., Niemann M., Pusnik M., Schmidt O., Burmann B. M., Hiller S., Meisinger C., Schneider A. and Wagner R. (2012)
Bacterial origin of a mitochondrial outer membrane protein translocase: New perspectives from comparative single channel electrophysiology
J. Biol. Chem. 287:31437-31445

  • Paper of the week (top 2% of JBC papers in overall importance) 

Desy S., Schneider A. and Mani J. (2012)
Trypanosoma brucei has a canonical mitochondrial processing peptidase
Mol. Biochem. Parasitol. 185:161-164

Pusnik M., Mani  J., Schmidt O., Niemann M., Oeljeklaus O., Schnarwiler F., Warscheid
B. , Lithgow T., Meisinger C. and Schneider A. (2012)

An essential novel component of the non-canonical mitochondrial outer membrane protein import system of trypanosomatids
Mol. Biol. Cell. 23:3420-3428

Pusnik M., Schmidt O., Perry A. J., Oeljeklaus S., Niemann M., Warscheid B.,
Meisinger C. Lithgow T. and Schneider A. (2012)

Response to Zarsky et al.
Curr. Biol. 22: R481-R482

  • Our response to a correspondence of Zarsky et al. (Curr. Biol. 2012. 22: R479-81) that challenges some conclusions of our 2011 Current Biology paper

Pusnik M. and Schneider A. (2012)
A trypanosomal pentatricopeptide repeat protein stabilizes the mitochondrial mRNAs of cytochrome oxidase subunit 1 and 2
Euk. Cell, 11:79-87

Rettig J., Wang Y., *Schneider A. and *Ochsenreiter T. (* joint last authors) (2012)
Dual targeting of isoleucyl-tRNA synthetase in Trypanosoma brucei is mediated through alternative trans-splicing
Nucleic Acids Res. 40:1299-1306

Pusnik M., Schmidt O., Perry A. J., Oeljeklaus S., Niemann M., Warscheid B., Lithgow T., Meisinger C. and Schneider A. (2011)
Mitochondrial preprotein translocase of trypanosomatids has a bacterial origin
Supplemental Information
Curr. Biol. 21:1738-1743

Tschopp F., Charrière F. and Schneider A. (2011)
In vivo study in Trypanosoma brucei links mitochondrial tRNA import to mitochondrial protein import.
EMBO reports, 12:825-832

Niemann M., Schneider A. and Cristodero M. (2011)
Mitochondrial translation in trypanosomatids: a novel target for chemotherapy?
Trends Parasitol. 27:429-433

Schneider A. (2011)
Mitochondrial tRNA import and its consequences for mitochondrial translation.
Annu. Rev. Biochem. 80:1033–53 / Review

Cristodero M., Seebeck T. and Schneider A. (2010)
Mitochondrial translation is essential in bloodstream forms of Trypanosoma brucei.
Mol. Microbiol. 78:757-769

Aeby E., Ullu E., Yepiskoposyan H., Schimanski B., Roditi I., Mühlemann O. and Schneider A. (2010)
tRNASec is transcribed by RNA polymerase II in Trypanosoma brucei but not in humans.
Nucleic Acids Res. 38:5833-5843

Pino P., Aeby E., Foth B.J., Sheiner L., Soldati T., Schneider A. and Soldati-Favre D. (2010)
Mitochondrial translation in absence of local tRNA aminoacylation and methionyl tRNA formylation in Apicomplexa.
Mol. Microbiol. 76(3):706-718

Lithgow T. and Schneider A. (2010)
Evolution of macromolecular import pathways in mitochondria, hydrogenosomes and mitosomes.
Phil. Trans. R. Soc. B. Sci. 365:799-817 / Review

Bruske E., Sendfeld F. and Schneider A. (2009)
Thiolated tRNAs of Trypanosoma brucei are imported into mitochondria and dethiolated after import.
J. Biol. Chem. 284:36491-9

Espanol Y., Thut D., Schneider A. and Ribas de Pouplana L. (2009)
A mechanism for functional segregation of mitochondrial and cytosolic genetic codes.
Proc. Natl. Acad. Sci. USA 106:19420-5

Aeby E., Seidel V. and Schneider A. (2009)
The selenoproteome is dispensable in bloodstream forms of Trypanosoma brucei.
Mol. Biochem. Parasitol. 168:191-193

Signorell A., Gluenz E., Rettig J., Schneider A., Hemphill A., Gull K. and Bütikofer P. (2009)
Perturbation of phosphatidylethanolamine synthesis affects mitochondrial morphology and cell cycle progression in procyclic form Trypanosoma brucei.
Mol. Microbiol. 72:1068-1079

Charriere F., O'Donoghue P., Helgadóttir S., Maréchal-Drouard L., Cristodero M., Horn E. K., Söll D. and Schneider A. (2009)
Dual targeting of a tRNAAsp requires two different aspartyl-tRNA synthetases in Trypanosoma brucei.
J. Biol. Chem. 284:16210-16217

Aeby E., Palioura S., Pusnik M., Marazzi J., Lieberman A., Ullu E., Söll D., Schneider A. (2009)
The canonical pathway for selenocysteine insertion is dispensable in Trypanosomes.
Proc. Natl. Acad. Sci. USA 106: 5088-5092


Pusnik M., Charrière F., Mäser P., Waller R., Dagley MJ., Lithgow T., Schneider A. (2009)

The single mitochondrial porin of Trypanosoma brucei is the main metabolite transporter in the outer mitochondrial membrane.
Mol Biol Evol. 26(3):671-80

Schneider A., Bursac D., Lithgow T. (2008)
The direct route: a simplified pathway for protein import into the mitochondrion of
trypanosomes

Trends Cell Biol. 18: 12-18 / Review

Schneider A., Bouzaidi-Tiali N., Chanez A.-L. and Bulliard L. (2007)
ATP production in isolated mitochondria of procyclic Trypanosoma brucei
Methods Mol. Biol. 372:379-87 / Review

Schneider A., Charrière F., Pusnik M. and Horn E. K.(2007)
Isolation of mitochondria from procyclic Trypanosoma brucei
Methods Mol. Biol. 372:67-80 / Review

Bouzaidi-Tiali N., Aeby E., Charrière F., Pusnik M. and Schneider A. (2007)
Elongation factor 1a mediates the specificity of mitochondrial tRNA import in T. brucei
EMBO J. 26(20):4302-12

Pusnik M., Small I., Read L. K., Fabbro T. and Schneider A. (2007)
Pentatricopeptide repeat proteins in T. brucei function in mitochondrial ribosomes
Mol. Cell. Biol. 27(19):6876-88

Bouzaidi-Tiali N., Giglione C., Bulliard Y., Pusnik M., Meinnel T. and Schneider A. (2007)
Type-3 peptide deformylases are required for oxidative phosphorylation in Trypanosoma
brucei

Mol. Microbiol. 65(5):1218-28

Hehl A. B., Regös A., Schraner E. and Schneider A. (2007)
Bax function in the absence of mitochondria in the primitive protozoan Giardia lamblia.
PLoS ONE 2(5): e488

Gentle I. E., Perry A. J., Alcock F. H., Likic V.A., Dolezal P., Ng E.T., Purcell A.W., McConnville M., Naderer T., Chanez A. L., Charriere F., Aschinger C.,  Schneider A., Tokatlidis K. and Lithgow T. (2007)
Conserved motifs reveal details of ancestry and structure in the small TIM chaperones of the mitochondrial intermembrane space
Mol. Biol. Evol. 24(5):1149-1160

Geslain R., Aeby E., Guitart T., Jones T. E., de Moura M.C., Charriere F., Schneider A., and de Pouplana L.R. (2006)
Trypanosoma seryl-tRNA synthetase is a metazoan-like enzyme with high affinity for tRNASec
J. Biol. Chem. 281: 38217-38225

Chanez A.-L., Hehl A., Engstler M. and Schneider A. (2006)
Inactivating the single dynamin of T. brucei blocks mitochondrial fission and endocytosis and leads to a precise cytokinesis arrest
J. Cell Sci. 119: 2968-2974

Charriere F, Helgadottir S, Horn E. K., Söll D. and Schneider A. (2006)
Dual targeting of a single tRNA(Trp) requires two different tryptophanyl-tRNA synthetases in Trypanosoma brucei
Proc. Natl. Acad. Sci. USA. 103: 6847-6852

Charrière F., Tan T. H. P. and Schneider A. (2005)
Mitchondrial initiation factor 2 of Trypanosoma brucei binds imported formylated elongator-type methionyl-tRNA
J. Biol. Chem. 280:15659-15665

Crausaz Esseiva A., Naguleswaran A., Hemphill A. and Schneider A. (2004)
Mitochondrial tRNA import in Toxoplasma gondii
J. Biol. Chem. 279: 42363-42368

Vassella E., Probst M., Schneider A., Studer E., Renggli C. K. and Roditi I. (2004)
Expression of a major surface protein of Trypanosoma brucei insect forms is controlled by the activity of mitochondrial enzymes
Mol. Biol. Cell 15: 3986-399325

Crausaz Esseiva A. , Maréchal-Drouard L., Cosset A. and Schneider A. (2004)
The T-stem determines the cytosolic or mitochondrial localization of trypanosomal methionyl-tRNAs
Mol. Biol. Cell 15: 2750-2757

Schneider A. and Ebert D. (2004)
Covariation of mitochondrial genome size with gene lengths: Evidence for gene length reduction during mitochondrial evolution
J. Mol. Evol. 59: 90-96

Crausaz Esseiva A., Chanez A.-L., Bochud-Allemann N., Martinou J.-C., Hemphill A. and Schneider A. (2004)
Temporal dissection of Bax-induced events leading to fission of the single mitochondrion in Trypanosoma brucei.
EMBO Rep. 5: 268-273

Rinehart J., Horn E. K. , Wei D. , Söll D. and Schneider A. (2004)
Trypanosoma brucei mitochondria use non-canonical eukaryal glutaminyl- and glutamyl-tRNA synthetases
J. Biol. Chem. 279: 1161-1166

Bochud-Allemann N. and Schneider A. (2002)         
Mitochondrial substrate level phosphorylation is essential for growth of procyclic T. brucei
J. Biol. Chem. 277: 32849-32854

Tan T. H. P., Pach R., Crausaz A., Ivens A. and Schneider A. (2002)
tRNAs in Trypanosoma brucei: genomic organization, expression and mitochondrial import
Mol. Cell. Biol. 22: 3707-3717

Tan T. H. P., Bochud-Allemann N., Horn E. K. and Schneider A. (2002)
Eukaryotic-type elongator tRNAMet of Trypanosoma brucei becomes formylated after import into mitochondria
Proc. Natl. Acad. Sci. USA 99: 1152-1157

Schneider A. (2001)
Does the evolutionary history of aminoacyl-tRNA synthetases may explain the loss of mitochondrial tRNA genes?
Trends Genet. 17: 557-558

Schneider A. (2001)
Unique aspects of mitochondrial biogenesis in trypanosomatids
Int. J. Parasitol.  31, 1403-1415 / Review

Schneider A. and Maréchal-Drouard L. (2000)
Mitochondrial tRNA import: are there distinct mechanisms?
Trends Cell Biol. 10: 509-513 / Review

Allemann N. and Schneider A. (2000)
ATP production in isolated mitochondria of procyclic Trypanosoma brucei
Mol. Biochem. Parasitol. 111: 87-94

Nabholz C. E., Horn E. K. and Schneider A. (1999)
tRNAs and proteins are imported into mitochondria of Trypanosoma brucei by two distinct mechanisms
Mol. Biol. Cell 10: 2547-2557

* Westermann S.,*Schneider A., Horn E. K. and Weber K. (1999) (* joint first authors)
Isolation of tubulin polyglutamylase from Crithidia; binding to microtubules and tubulin, glutamylation of mammalian brain alpha- and beta- tubulins
J. Cell Sci. 112: 2185-2193

Nabholz C. E., Speijer D. and Schneider A. (1999)
Chloramphenicol-sensitive mitochondrial translation in Trypanosoma brucei
Parasitol. Res. 85: 779-782

Schneider A., Plessmann U., Felleisen R. and Weber K. (1999)
Alpha-tubulins of Tritrichomonas mobilensis are encoded by multiple genes and are not posttranslationally tyrosinated
Parasitol. Res. 85: 246-248

Schneider A., Plessmann U., Felleisen R. and Weber K. (1998)
Posttranslational modifications of trichomonad tubulins; identification of multiple glutamylation sites
FEBS lett. 429: 399-402

Sbicego S., Nabholz C., Hauser R., Blum B. and Schneider A. (1998)
In vivo import of unspliced tRNATyr containing synthetic introns of variable length into mitochondria of Leishmania tarentolae
Nucleic Acids Res. 26: 5251-5255

Weber K., Schneider A., Westermann S, Müller  N. and Plessmann U. (1997)
Posttranslational modifications of tubulin in Giardia lamblia, an ancient eukaryote
FEBS lett. 419: 87-91

Nabholz C. E. ,  Hauser R. and Schneider A. (1997)
Leishmania tarentolae contains distinct cytosolic and mitochondrial glutaminyl-tRNA synthetase activities
Proc. Natl. Acad. Sci. USA 94: 7903-7908

Schneider A., Plessmann U. and Weber K. (1997)
Supellicular and flagellar microtubules of Trypanosoma brucei are extensively glutamylated
J. Cell Sci. 110: 431-437

Weber K., Schneider A., Müller N. and Plessmann U. (1996)
Polygycylation of tubulin in the diplomonad Giardia lamblia, one of the oldest eukaryotes
FEBS lett. 393: 27-30

Schneider A. (1996)
Cytosolic yeast tRNAHis is covalently modified when imported into mitochondria of Trypanosoma brucei
Nucleic Acids Res. 24: 1225-1228

Hauser R., Pypaert M., Häusler T., Horn E. K. and Schneider A. (1996)
In vitro import of proteins into mitochondria of Trypanosoma brucei and Leishmania tarentolae
J. Cell Sci. 109: 517-523

Hauser R. and Schneider A. (1995)
tRNAs are imported into mitochondria of Trypanosoma brucei independent of their genomic context and of their genetic origin
EMBO J. 14: 4212-4220

Schneider A., McNally K. P. and Agabian N. (1994)
Nuclear-encoded mitochondrial tRNAs of Trypanosoma brucei have a modified cytidine in the anticodon loop
Nucleic Acids Res. 22: 3699-3705

Schneider A., Martin J. and Agabian N. (1994)
A nuclear-encoded tRNA  of Trypanosoma brucei is imported into mitochondria
Mol. Cell. Biol. 14: 2317-2322

Schneider A. (1994)
Import of RNA into mitochondria
Trends Cell Biol. 4: 282-286 / Review

Schneider A., Oppliger W. and Jenö P. (1994)
Purified Inner membrane protease I of yeast mitochondria is a heterodimer
J. Biol. Chem. 269: 1-4

Schneider A., McNally K. P. and Agabian N. (1993)
Splicing and 3'-processing of the tyrosine tRNA of Trypanosoma brucei
J. Biol. Chem. 268: 21868-21874

Schneider A., Behrens M., Pratje E., Michaelis G. and Schatz G. (1991)
Inner membrane protease I, an enzyme mediating intramitochondrial protein sorting in yeast
EMBO J. 10: 247-254

Kueng V., Schlaeppi  K., Schneider A. and Seebeck T. (1989)
A glycosomal protein (p60) which is predominantly expressed in procyclic Trypanosoma brucei 
J. Biol. Chem. 246: 5203- 5209

Schneider A., Hemphill A., Wyler T. and Seebeck T. (1988)
Large microtubule-associated protein of Trypanosoma brucei has tandemly repeated, near-identical sequences
Science 241: 459- 462

Schneider A., Eichenberger W. and Seebeck T. (1988)
A microtubule-binding protein of Trypanosoma brucei which contains covalently bound fatty acid         
J. Biol. Chem. 263: 6472- 6476

Schneider A., Lutz H. U., Marugg R., Gehr P. and Seebeck T. (1988)
Spectrin-like proteins in the paraflagellar rod structure of Trypanosoma brucei brucei
J. Cell Sci. 90: 307-315

Sherwin T., Schneider A., Sasse R., Seebeck T. and Gull K. (1987)
Distinct localization and cell cycle dependence of c-terminally tyrosylated alpha-tubulin  in the microtubules of Trypanosoma brucei brucei
J. Cell Biol. 104: 439- 446

Schneider A., Sherwin T., Sasse R., Russell D. G., Gull K. and Seebeck T. (1987)
Subpellicular and flagellar microtubules of Trypanosoma brucei brucei contain the same alpha-tubulin isotypes
J. Cell Biol. 104: 431- 438

Gull K., Hussey P. J., Sasse R., Schneider A., Seebeck T. and Sherwin T. (1986)
Tubulin isotypes: Generation of diversity in cells and microtubular organelles
J. Cell Sci. Suppl. 5: 243- 255

     

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